Ermandiasa Gede, 32, passed away on Tuesday nine days after being hospitalised in Livorno, despite intensive attempts to save him.
MSC Cruises released a statement expressing its sadness at the news of his death, while praising the efforts of the Italian hospital staff.
Three colleagues were also taken ill on the 92,000-gt MSC Orchestra(built 1997).
According to the company, a 47-year-old Italian cook from the ship was still on life support, but his condition had "improved markedly" in recent days.
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